“Out of these sixty-four items, five items—namely, offering water to the tulasī tree, hearing Śrīmad-Bhāgavatam, associating amongst the devotees, saṅkīrtana and living in Mathurā—are very important”
CC Antya 3.137, Although Kṛṣṇa wants everyone to surrender to His lotus feet, because of people’s sinful activities they cannot do this.
Na māṁ duṣkṛtino mūḍhāḥ prapadyante narādhamāḥ: (BG 7.15) rascals and fools, the lowest of men, who engage in sinful activities, cannot suddenly surrender to the lotus feet of Kṛṣṇa. Nevertheless, if they begin chanting the Hare Kṛṣṇa mantra and rendering service unto the tulasī plant, they will very soon be able to surrender. One’s real duty is to surrender to the lotus feet of Kṛṣṇa, but if one is unable to do so, he should adopt this process, as introduced by Śrī Caitanya Mahāprabhu and His most confidential servant, Nāmācārya Śrīla Haridāsa Ṭhākura. This is the way to achieve success in Kṛṣṇa consciousness.Therefore She worshiped the tulasī plant, following in the footsteps of her spiritual master.
The conclusion is that associating with a Vaiṣṇava, chanting the holy name of the Lord and offering obeisances to the tulasī plant or a Vaiṣṇava all lead one to become a transcendental devotee who is completely cleansed of all material contamination.